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Soyasaponin Ameliorates Obesity and Reduces Hepatic Triacylglycerol Accumulation by Suppressing Lipogenesis in High‐fat Diet‐fed Mice by Wei‐Ting Tsai; Yuki Nakamura; Taiki Akasaka; Yoshinori Katakura; Yasutake Tanaka; Bungo Shirouchi; Zhe Jiang; Xingyu Yuan; Masao Sato is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Soyasaponin Ameliorates Obesity and Reduces Hepatic Triacylglycerol Accumulation by Suppressing Lipogenesis in High‐fat Diet‐fed Mice about?
Soyasaponins are triterpenoid glycosides found in soybean. We investigated whether soyasaponin ameliorates lipid metabolism and its possible mechanisms. In C57BL/6J mice fed a high-fat diet (HFD), soyasaponin (SAP) was orally administered for 9 weeks. Additionally, we evaluated the effect of soyasapogenols on 3T3-L1 adipocytes. In HFD-fed mice, the SAP significantly reduced body weight by 7% and relative adipose tissue weight by 35%. X-ray computed tomography demonstrated that the SAP reduced visceral and subcutaneous adipose tissue weights during week 3 of feeding. The SAP reduced sterol regulatory element-binding protein-1c (SREBP-1c) mRNA levels by 32% in the epididymal adipose tissue, significantly decreasing the triacylglycerol (TAG) content by 37% and SREBP-1c and fatty acid synthase mRNA levels by 52% and 61%, respectively, in the liver. In 3T3-L1 adipocytes, soyasapogenol B significantly decreased lipid droplets. The SAP containing soyasaponin A and B as conjugates demonstrate anti-obesity effects by suppressing adipocyte differentiation and lipogenesis, with a preventive effect on hepatic TAG accumulation by suppressing lipogenesis. Practical Application: Soyasaponin is on
Who reads Soyasaponin Ameliorates Obesity and Reduces Hepatic Triacylglycerol Accumulation by Suppressing Lipogenesis in High‐fat Diet‐fed Mice?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Wei‐Ting Tsai; Yuki Nakamura; Taiki Akasaka; Yoshinori Katakura; Yasutake Tanaka; Bungo Shirouchi; Zhe Jiang; Xingyu Yuan; Masao Sato
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)