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Synthesis, cytotoxic activity, DNA topoisomerase-II inhibition, molecular modeling and structure–activity relationship of 9-anilinothiazolo[5,4-b]quinoline derivatives by Marco A. Loza-Mejía; Susana Olvera-Vázquez; Karina Maldonado-Hernández; Teresita Guadarrama-Salgado; Ignacio González-Sánchez; Fernando Rodríguez-Hernández; José D. Solano; Rogelio Rodríguez-Sotres; Alfonso Lira-Rocha is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Some novel 9-anilinothiazolo [5,4-b]quinoline derivatives were synthesized and their cytotoxic activities were examined. The inhibition of some of the most active compounds over human topoisomerase II (Topo II) activity was assessed with the kDNA decatenation assay. The novel compounds differ in the substituents attached to the anilino ring, a dialkylamino alkylamino group, a saturated heterocyclic moiety, a methylthio group at position 2 and a fluorine atom present or absent at 7-position. According to the data, compounds with a diethylaminopropylamino group and a chlorine atom at 4 0 -position of the anilino ring were the most cytotoxic. The molecular models of all compounds indicated a correlation between hydrophobicity and cytotoxic activity although the direction and magnitude of the dipole moment also had a significant influence on its cytotoxicity. The 2-dialkylaminoalkylamino substituent is flexible and is known to facilitate the crossing of cell membranes; thus, this last barrier may be a limiting step in the mechanisms mediating the cytotoxicity. On the other hand, the activity of 2-methylthio derivatives seems to rely more on the electronic effects brought about by the s

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Author

Marco A. Loza-Mejía; Susana Olvera-Vázquez; Karina Maldonado-Hernández; Teresita Guadarrama-Salgado; Ignacio González-Sánchez; Fernando Rodríguez-Hernández; José D. Solano; Rogelio Rodríguez-Sotres; Alfonso Lira-Rocha

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)