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Archaic NOVA1 Variant Impacts Neurodevelopment by Mércia Fiuza is a document available to read on EtoBox.
What is Archaic NOVA1 Variant Impacts Neurodevelopment about?
The study investigates the impact of reintroducing the archaic variant of the NOVA1 gene, found in Neanderthals and Denisovans, into human induced pluripotent stem cells to observe its effects on neurodevelopment in cortical organoids. Results indicate that this archaic variant alters alternative splicing, neural network function, and synaptic connectivity, suggesting it may have played a significant role in the evolution of modern humans. The findings highlight the functional consequences of human-specific
- Author
- Mércia Fiuza
- Language
- EN