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Safety and Feasibility of Percutaneous Retrograde Coronary Sinus Delivery of Autologous Bone Marrow Mononuclear Cell Transplantation in Patients with Chronic Refractory Angina by Jorge Tuma; Roberto Fernández-Viña; Antonio Carrasco; Jorge Castillo; Carlos Cruz; Alvaro Carrillo; Jose Ercilla; Carlos Yarleque; Jaime Cunza; Timothy D Henry; Amit N Patel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Safety and Feasibility of Percutaneous Retrograde Coronary Sinus Delivery of Autologous Bone Marrow Mononuclear Cell Transplantation in Patients with Chronic Refractory Angina about?
## Background Chronic refractory angina is a challenging clinical problem with limited treatment options. The results of early cardiovascular stem cell trials using ABMMC have been promising but have utilized intracoronary or intramyocardial delivery. The goal of the study was to evaluate the safety and early efficacy of autologous bone marrow derived mononuclear cells (ABMMC) delivered via percutaneous retrograde coronary sinus perfusion (PRCSP) to treat chronic refractory angina (CRA). ## Methods From May 2005 to October 2006, 14 patients, age 68 +/- 20 years old, with CRA and ischemic stress-induced myocardial segments assessed by SPECT received a median 8.19\*10^8^ ± 4.3\*10^8^ mononuclear and 1.65\*10^7^ ± 1.42\*10^7^ CD34^+^ cells by PRCSP.. ## Results ABMMC delivery was successful in all patients with no arrhythmias, elevated cardiac enzymes or complications related to the delivery. All but one patient improved by at least one Canadian Cardiovascular Society class at 2 year follow-up compared to baseline (p < 0.001). The median baseline area of ischemic myocardium by SPECT of 38.2% was reduced to 26.5% at one year and 23.5% at two years (p = 0.001). The median rest left vent
Who reads Safety and Feasibility of Percutaneous Retrograde Coronary Sinus Delivery of Autologous Bone Marrow Mononuclear Cell Transplantation in Patients with Chronic Refractory Angina?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jorge Tuma; Roberto Fernández-Viña; Antonio Carrasco; Jorge Castillo; Carlos Cruz; Alvaro Carrillo; Jose Ercilla; Carlos Yarleque; Jaime Cunza; Timothy D Henry; Amit N Patel
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2003-; Springer Science and Business Media LLC (ISSN 1479-5876)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)