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Investigation into the potential of low-frequency ultrasound facilitated topical delivery of Cyclosporin A by Hongzhuo Liu; Sanming Li; Weisan Pan; Yongjun Wang; Fei Han; Huimin Yao is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Investigation into the potential of low-frequency ultrasound facilitated topical delivery of Cyclosporin A about?

The potential for low-frequency ultrasound facilitated topical transport of Cyclosporin A was investigated using rat skin. Studies of intensity and exposure time acting on the deposition of Cyclosporin A into deeper skin of in vitro sonophoresis were performed. Low-frequency ultrasound increased the amount of Cyclosporin A retained in the skin only seven times than the passive diffusion. Furthermore, we also tested the synergistic effect of ultrasound and other approaches such as chemical enhancers and electroporation on topical drug delivery of Cyclosporin A. We found that the efficacy of low-frequency ultrasound in enhancing topical delivery could be further increased by pretreatment of skin with chemical enhancers, such as laurocapram (Azone) and sodium lauryl sulfate (SLS). Meanwhile only a small amount was seen to across the full skin into the receiver compartment. Trimodality treatment comprising of pretreatment with Azone+ultrasound in combination followed by electroporation was not effective in enhancing the topical delivery of Cyclosporin A. However, this combination strategy increased the penetration of Cyclosporin A through rat skin by order of 15. The histopathological

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Author

Hongzhuo Liu; Sanming Li; Weisan Pan; Yongjun Wang; Fei Han; Huimin Yao

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2006

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)