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Minimum detectable difference of MR diffusion maps in acute ischemic stroke by Ashley D. Harris; Mirthula Govindaraj; Richard Frayne is a Medicine article available to read on EtoBox.

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## Abstract ## Purpose To determine the minimum detectable difference (MDD) and investigate variability of region‐of‐interest (ROI) analysis of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in acute ischemic stroke. ## Materials and Methods Ten patients with acute stroke (<24 hours) and moderate‐to‐large infarcts were imaged using a fast diffusion tensor technique. Four observers repeated three trials, during which each of two ROI types (free‐hand polygon and ellipse) were drawn in white and gray matter (WM and GM) on FA and ADC maps. Analysis‐of‐variance techniques examined tissue and ROI type effects as well as inter‐ and intraobserver variability. F‐tests examined the variability differences between ROI types. ## Results The MDD for ADC was 0.160 × 10^−3^ mm^2^ s^−1^ in WM and 0.212 × 10^−3^ mm^2^ s^−1^ in GM. The FA MDD was 0.19 in WM and 0.10 in GM. Tissue but not ROI type affected the mean values for both ADC and FA maps. Intraobserver reliability was substantial, while interobserver reliability was poor‐to‐moderate. No variability differences were found by ROI types. ## Conclusion The MDD for WM and GM in normal and ischemic tissue were calculated. Inte

Who reads Minimum detectable difference of MR diffusion maps in acute ischemic stroke?

Author

Ashley D. Harris; Mirthula Govindaraj; Richard Frayne

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)

Published

2008

Language

EN

Field

Medicine (Health Sciences)