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A Prospective Randomized Double-blind Trial Comparing Ondansetron Versus Prochlorperazine for the Prevention of Nausea and Vomiting in Patients Undergoing Fractionated Radiotherapy by T.J. Priestman; J.T. Roberts; B.K. Upadhyaya is a Agricultural and Biological Sciences article available to read on EtoBox.

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In a multicentre, international doubleblind trial, patients undergoing courses of five or more daily radiotherapy treatments to the upper abdomen were randomized to receive either oral ondansetron 8 mg t.d.s, or oral prochlorperazine 10 mg t.d.s, throughout their radiation course in order to try to prevent nausea and vomiting. A total of 192 patients were recruited, 135 of whom were included m the efficacy analysis; of these, 70 received ondansetron and 65 prochlorperazine. Forty-three (61%) of the patients prescribed ondansetron and 23 (35%) of those given prochlorperazine had a complete response, with no emetic episodes throughout their treatment course (P=0.002). There was, however, no significant difference between the two groups with respect to the incidence and severity of nausea. Seventeen (24%) of the patients on ondansetron and 19 (29%) of those given prochlorperazine were treatment failures, experiencing more than five emetic episodes on their worst day during the study. Both drugs were well tolerated, although constipation was seen more commonly with ondansetron.

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Author

T.J. Priestman; J.T. Roberts; B.K. Upadhyaya

Publisher

Elsevier Science; Springer; Elsevier ; Springer-Verlag; W. B. Saunders Co., Ltd.; Springer Verlag; Elsevier BV; Springer Science and Business Media LLC (ISSN 1433-2981)

Published

1993

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)