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Can I read Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder on EtoBox?
Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder by Andrew W. Zimmerman; Kanwaljit Singh; Susan L. Connors; Hua Liu; Anita A. Panjwani; Li-Ching Lee; Eileen Diggins; Ann Foley; Stepan Melnyk; Indrapal N. Singh; S. Jill James; Richard E. Frye; Jed W. Fahey is a Neuroscience article available to read on EtoBox.
What is Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder about?
## Background Sulforaphane (SF), an isothiocyanate in broccoli, has potential benefits relevant to autism spectrum disorder (ASD) through its effects on several metabolic and immunologic pathways. Previous clinical trials of oral SF demonstrated positive clinical effects on behavior in young men and changes in urinary metabolomics in children with ASD. ## Methods We conducted a 15-week randomized parallel double-blind placebo-controlled clinical trial with 15-week open-label treatment and 6-week no-treatment extensions in 57 children, ages 3–12 years, with ASD over 36 weeks. Twenty-eight were assigned SF and 29 received placebo (PL). Clinical effects, safety and tolerability of SF were measured as were biomarkers to elucidate mechanisms of action of SF in ASD. ## Results Data from 22 children taking SF and 23 on PL were analyzed. Treatment effects on the primary outcome measure, the Ohio Autism Clinical Impressions Scale (OACIS), in the general level of autism were not significant between SF and PL groups at 7 and 15 weeks. The effect sizes on the OACIS were non-statistically significant but positive, suggesting a possible trend toward greater improvement in those on treatment with
Who reads Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Andrew W. Zimmerman; Kanwaljit Singh; Susan L. Connors; Hua Liu; Anita A. Panjwani; Li-Ching Lee; Eileen Diggins; Ann Foley; Stepan Melnyk; Indrapal N. Singh; S. Jill James; Richard E. Frye; Jed W. Fahey
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Neuroscience (Life Sciences)