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Can I read Genetic control of chicken heterophil function in advanced intercross lines: associations with novel and with known Salmonella resistance loci and a likely mechanism for cell death in extracellular trap production on EtoBox?
Genetic control of chicken heterophil function in advanced intercross lines: associations with novel and with known Salmonella resistance loci and a likely mechanism for cell death in extracellular trap production by Sarah B. Redmond; Phongsakorn Chuammitri; Claire B. Andreasen; Dušan Palić; Susan J. Lamont is a Immunology and Microbiology article available to read on EtoBox.
What is Genetic control of chicken heterophil function in advanced intercross lines: associations with novel and with known Salmonella resistance loci and a likely mechanism for cell death in extracellular trap production about?
Heterophils, the avian polymorphonuclear leukocyte and the counterpart of mammalian neutrophils, generate the primary innate response to pathogens in chickens. Heterophil performance against pathogens is associated with host disease resistance, and heterophil gene expression and function are under genetic control. To characterize the genomic basis of heterophil function, heterophils from F~13~ advanced intercross chicken lines (broiler × Leghorn and broiler × Fayoumi) were assayed for phagocytosis and killing of __Salmonella enteritidis__, oxidative burst, and extracellular trap production. A whole-genome association analysis of single nucleotide polymorphisms at 57,636 loci identified genomic locations controlling these functional phenotypes. Genomic analysis revealed a significant association of extracellular trap production with the __SAL1__ locus and the __SLC11A1__ gene, which have both been previously associated with resistance to __S. enteritidis__. Fine mapping supports __SIVA1__ as a candidate gene controlling __SAL1__-mediated resistance and indicates that the proposed cell-death mechanism associated with extracellular trap production, ETosis, likely functions through the
Who reads Genetic control of chicken heterophil function in advanced intercross lines: associations with novel and with known Salmonella resistance loci and a likely mechanism for cell death in extracellular trap production?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Sarah B. Redmond; Phongsakorn Chuammitri; Claire B. Andreasen; Dušan Palić; Susan J. Lamont
- Publisher
- Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0093-7711)
- Published
- 2011
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)