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Measurement of Nuchal Translucency for Prenatal Screening of Congenital Heart Defects: a Population‐based Evaluation by Jean‐Marie Jouannic; Anne‐Claire Thieulin; Damien Bonnet; Lucile Houyel; Nathalie Lelong; François Goffinet; Babak Khoshnood is a Medicine article available to read on EtoBox.
What is Measurement of Nuchal Translucency for Prenatal Screening of Congenital Heart Defects: a Population‐based Evaluation about?
## Objectives (1) Assess sensitivity of the measurement of nuchal translucency (NT), for the prenatal screening of congenital heart defect (CHD) on population‐based data; (2) examine whether the sensitivity of NT varies for specific types of cardiac defects. ## Methods Using population‐based data of the Paris Registry of Congenital Malformation for 935 fetuses with CHD and without chromosomal anomalies for the period 2001 to 2007, we calculated sensitivity of NT, its positive predictive value and likelihood ratio, for all CHD and for six types of CHD. ## Results Sensitivity of NT was 7.1 and 4.2% for the 2.5 and 3.5 mm cut‐off values, respectively; when isolated ventricular septal defects were excluded, sensitivity increased to 9.9 and 6.3%. Positive predictive values were 1.1 and 3.2% for 2.5 and 3.5 mm cut‐offs, respectively. Of the six defects examined, sensitivity of NT was highest for heterotaxy followed by hypoplastic left heart syndrome and coarctation of aorta. ## Conclusion Prevalence of CHD was about fourfold higher for fetuses with NT ≥ 3.5 mm (3.2%) than in the general population. This higher risk is comparable to that of other risk factors commonly used for early refer
Who reads Measurement of Nuchal Translucency for Prenatal Screening of Congenital Heart Defects: a Population‐based Evaluation?
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- Author
- Jean‐Marie Jouannic; Anne‐Claire Thieulin; Damien Bonnet; Lucile Houyel; Nathalie Lelong; François Goffinet; Babak Khoshnood
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0197-3851)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)