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Expanding sports drug testing assays: Mass spectrometric characterization of the selective androgen receptor modulator drug candidates RAD140 and ACP‐105 by Mario Thevis; Thomas Piper; Simon Beuck; Hans Geyer; Wilhelm Schänzer is a Chemistry article available to read on EtoBox.

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## RATIONALE Anabolic agents have been top‐ranked for many years among statistics of adverse analytical findings compiled by the World Anti‐Doping Agency (WADA). Besides archetypical anabolic‐androgenic steroids (AAS), alternative substances with similar effects concerning bone and muscle anabolism have been therapeutically pursued. A prominent emerging class of drugs is the chemically heterogeneous group of selective androgen receptor modulators (SARMs), some of which have been detected in doping control samples between 2009 and 2012 despite missing clinical approval. ## METHODS In order to support the momentum of expanding the preventive and proactive measures among anti‐doping laboratories, the analytical characterization of substances with misuse potential is of great importance. In the present study, the SARM drug candidates RAD140 (comprising a 5‐phenyloxadiazole nucleus) and ACP‐105 (bearing an __N__‐substituted tropanol pharmacophore) were studied regarding their mass spectrometric behavior under ESI‐MS(/MS) and EI‐MS(/MS) conditions. Reference material was synthesized according to established protocols and dissociation pathways of RAD140 and ACP‐105 were elucidated with li

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Author

Mario Thevis; Thomas Piper; Simon Beuck; Hans Geyer; Wilhelm Schänzer

Publisher

Wiley

Published

2013

Language

EN

Field

Chemistry (Physical Sciences)