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Six bioabsorbable polymers: In vitro acute toxicity of accumulated degradation products by M. S. Taylor; A. U. Daniels; K. P. Andriano; J. Heller is a Medicine article available to read on EtoBox.

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Bioabsorbable polymer implants may provide a viable alternative to metal implants for internal fracture fixation. One of the potential difficulties with absorbable implants is the possible toxicity of the polymeric degradation products especially if they accumulate and become concentrated. Accordingly, material evaluation must involve dose-response toxicity data as well as mechanical properties and degradation rates. In this study the toxicity and rates of degradation for six polymers were determined, along with the toxicity of their degradation product components. The polymers studied were poly(glyco1ic acid) (PGA), two samples of poly(L-lactic acid) (PLA) having different molecular weights, poly(ortho ester) (POE), poly(t-caprolactone) (PCL), and poly(hydroxy butyrate valerate) (5% valerate) (PHBV). Polymeric specimens were incubated at 37°C in 0.05 M Tris buffer (pH 7.4 at 37°C) and sterile deionized water. The solutions were not changed during the incubation intervals, providing a worst-case model of the effects of accumulation of degradation products. The pH and acute toxicity of the incubation solutions and the mass loss and logarithmic viscosity number of the polymer samples

Who reads Six bioabsorbable polymers: In vitro acute toxicity of accumulated degradation products?

Author

M. S. Taylor; A. U. Daniels; K. P. Andriano; J. Heller

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1045-4861)

Published

1994

Language

EN

Field

Medicine (Health Sciences)