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This systematic review and meta-analysis evaluated the diagnostic accuracy of the Prostate Health Index (PHI) and the 4-kallikrein panel for detecting overall and high-grade prostate cancer (PCa). The analysis included 28 studies with 16,762 patients, revealing that PHI had a sensitivity of 0.89 and specificity of 0.34, while the 4K panel had a sensitivity of 0.74 and specificity of 0.60 for PCa detection. Both tests demonstrated good diagnostic accuracy, with AUC values of 0.76 for PHI and 0.72 for the 4K

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huanghongxin85

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EN