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Archaeal bundling pili of Pyrobaculum calidifontis reveal similarities between archaeal and bacterial biofilms by Fengbin Wang; Virginija Cvirkaite-Krupovic; Mart Krupovic; Edward H. Egelman is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Archaeal bundling pili of Pyrobaculum calidifontis reveal similarities between archaeal and bacterial biofilms about?

## Significance Biofilms are communities of microbes where cells attach to each other as well as to various surfaces. Bacterial biofilms have been intensively studied due to their importance in many infections, whereas much less is known about biofilms in Archaea, the third domain of life. Using cryo-electron microscopy, we have determined the atomic structure of a surface filament that forms bi-polar bundles connecting archaeal cells. We show that the major protein of these bundling pili has common ancestry with a protein known to be an important component of bacterial biofilms. This adds to our understanding of the evolutionary relationship between bacteria and archaea and may provide new insights into bacterial biofilms.

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Author

Fengbin Wang; Virginija Cvirkaite-Krupovic; Mart Krupovic; Edward H. Egelman

Publisher

Proceedings of the National Academy of Sciences

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)