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We have reported the presence of the lysophosphatidic acid (LPA) receptor subtypes (LPARs) LPA1 and LPA3 on the intact human periodontal ligament (huPDL) (Cerutis et al. 2016). LPA 18:1 significantly modulates a multitude of inflammatory transcripts in human gingival fibroblasts (Cerutis et al. 2015) supporting LPARs as having a regulatory role in chronic periodontal disease (PD). Members of the LPA, platelet-activating factor (PAF) and prostaglandin (EP) GPCRs can localize to the nuclear membrane in mamm
- Author
- Shakeel Khan
- Language
- EN