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Prognosis Value of Platelet Counts, Albumin and Neutrophil-Lymphocyte Ratio of Locoregional Recurrence in Patients with Operable Head and Neck Squamous Cell Carcinoma by Ye, Jing; Liao, Bing; Jiang, Xiaohua; Dong, Zhihuai; Hu, Sunhong; Liu, Yuehui; Xiao, Mang is a Medicine article available to read on EtoBox.
What is Prognosis Value of Platelet Counts, Albumin and Neutrophil-Lymphocyte Ratio of Locoregional Recurrence in Patients with Operable Head and Neck Squamous Cell Carcinoma about?
## Background Peripheral blood inflammation factor neutrophil-lymphocyte ratio (NLR), platelet count (PLT) and nutritional factor serum albumin (ALB) have been proposed as prognostic markers of head and neck squamous carcinoma cancer (HNSCC) in recent years. In the current study, nomogram predict models based on pre-treatment hematological parameters and a modified risk-stratified score system have been built. ## Methods A total of 197 patients with oropharyngeal, hypopharyngeal and laryngeal cancers receiving multimodality treatment between 2012 and 2014 were included. The pre-treatment ALB, neutrophil, lymphocyte and platelet count (PLT) were detected. Cancer-specific survival and locoregional recurrence (LRC) by 5 years’ follow-up in the cases were obtained. To integrate clinical characteristics, we propose a modified risk-stratified score system. Kaplan–Meier method, proportional hazards COX model, logistic models were used to establish nomograms within external validation. ## Results Five-year LRC was decreased (p=0.004) for 140 patients with pre-treatment NLR 248×10^9^/L were better among tested models. On Bayesian information criteria (BIC) analysis, the optimal prognostic
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- Author
- Ye, Jing; Liao, Bing; Jiang, Xiaohua; Dong, Zhihuai; Hu, Sunhong; Liu, Yuehui; Xiao, Mang
- Publisher
- Dove Press Ltd.; Dove Medical Press; Dove Medical Press Ltd; [Auckland N.Z.]: Dove Medical Press, c2009-; Informa UK Limited; Dove Medical Press Ltd. (ISSN 1179-1322)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)