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Anticancer and antimicrobial activities of new thiazolyl-urea derivatives: gene expression, DNA damage, DNA fragmentation and SAR studies by Farid M. Sroor; Abdelmageed M. Othman; Mohamad M. Aboelenin; Karima F. Mahrous is a Chemistry article available to read on EtoBox.

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The drug resistance became the major challenge in the antimicrobial and anticancer drugs therapy. Therefore, there is an urgent need to looking for new types of antimicrobial and anticancer agents. Herein we reported the synthesis and biological evaluation of a new series of N-Aryl-N′-2-thiazolylsulfonylurea (9-13) and N-Aryl-N′-2-thiazolyl-urea (15-19) derivatives. The prepared compounds (9-13 and 15-19) have been fully characterized by 1 H-NMR, 13 C NMR, IR, and elemental analysis. The antimicrobial activity was investigated against B. mycoides, E. coli, and C. albicans and the in vitro anticancer activity was tested against A549, HCT116, PC3, A431, HePG2, PACA2 and BJ1 cell lines using MTT assay. Compounds 9 and 11 were able to inhibit the microbial growth of B. mycoides, E. coli, and C. albicans by a width of inhibition zone ranged between 31 and 27 mm, which were higher than the positive antibiotic control (17 mm). The estimated values of MIC for both compounds 9 and 11 were found to be microbial species dependent, and they were varied between 0.156 and 0.039 mg/ ml. The in vitro anticancer activity showed that compounds 9, 10 and 11 were found to be the most promising with IC

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Author

Farid M. Sroor; Abdelmageed M. Othman; Mohamad M. Aboelenin; Karima F. Mahrous

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Chemistry (Physical Sciences)