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Can I read Synthesis and anti HIV-1 activity of new thiadiazepindioxides on EtoBox?
Synthesis and anti HIV-1 activity of new thiadiazepindioxides by Danilo Giannotti; Giovanni Viti; Rossano Nannicini; Vittorio Pestellini; Daniela Bellarosa is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and anti HIV-1 activity of new thiadiazepindioxides about?
New pyridobenzo-and dipyridothiadiazepindioxides 3-5 and two isomers 13-14 were synthetized and their anti HIV-1 activity and the cytotoxicity were evaluated in vitro. A good antiviral activity was shown by pyridobenzothiadiazepindioxides 4, compound 4a being the best. The human immunodeficiency virus type 1 (HIV-1) reverse transcriptase is an important target for the development of potent and effective drugs against the acquired immunodeficiency syndrome (AIDS) l, since the process of reverse transcription is an essential step in the HIV-1 life cycle. Recently several non-nucleoside reverse transcriptase inhibitors (NNRTIs) such as Nevirapine, TIBO, 0t-APA, Pyridinones and Bis(heteroaryl)piperazines have been introduced in clinical trials 2.
Who reads Synthesis and anti HIV-1 activity of new thiadiazepindioxides?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Danilo Giannotti; Giovanni Viti; Rossano Nannicini; Vittorio Pestellini; Daniela Bellarosa
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 1995
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)