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ChemInform Abstract: Synthesis of 2,4-Diamino-5,6,7,8,9,10-hexahydro-5,9-methanopyrimido[4,5-b]azocine. by Edward C. Taylor; James E. Dowling; Beena Bhatia is a Chemistry article available to read on EtoBox.

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## Synthesis of 2,4- 6,7,8,9,9methanopyrimido[4,azocine. -Optimization of direct annulation of triaminopyrimidine (I) with cyclohexenone (II) is achieved using acetic acid as solvent in a screw-capped pressure tube that is heated at 120 • C for 18 hours. Compound (VII) as prototype, its derivative (IX), as well as further derivatives resulting from substitution at bridgehead position C-9 are of interest as potential selective inhibitors of fungal (i.e. Pneumocystis carinii) dihydrofolate reductase (DHFR) to prevent AIDS patients from pneumonia infection. -(TAYLOR,

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Author

Edward C. Taylor; James E. Dowling; Beena Bhatia

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley (ISSN 0931-7597)

Published

1999

Language

EN

Field

Chemistry (Physical Sciences)