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Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis by Helena Vaverkova; David Karasek; Dalibor Novotny; Dagmar Jackuliakova; Jiri Lukes; Milan Halenka; Jiri Frohlich is a Medicine article available to read on EtoBox.

What is Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis about?

## Objective: To characterize the differences in various risk factors for atherosclerosis between individuals with apob higher (h) and lower (l) than predicted from regression equation apob vs ldl-c. ## Methods: We evaluated 391 dyslipidemic subjects not treated with hypolipidemic drugs. the measured parameters included lipid profile, apolipoproteins a-1 and b, markers of insulin resistance and inflammation/hemostasis. ## Results: Correlation coefficient between apob and ldl-c was 0.9 (p<0.0001). individuals with h apob compared to l apob had significantly higher sex and age adjusted bmi, waist circumference, insulin, homa (fasting insulinglucose/22.5), c-peptide, proinsulin, pai-1, sicam-1, svcam-1, t-pa, vwf, frequency of metabolic syndrome and lower values of tc, ldl-c and hdl-c (p<0.05 to <0.001 for all parameters). ## Conclusion: Individuals with apob higher than predicted by their ldl-c levels are more insulin resistant and have more atherogenic risk profile. thus, at least for dyslipidemic patients with high cardiometabolic risk, apob is a more appropriate marker of risk than ldl-c.

Who reads Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis?

Author

Helena Vaverkova; David Karasek; Dalibor Novotny; Dagmar Jackuliakova; Jiri Lukes; Milan Halenka; Jiri Frohlich

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)

Published

2009

Language

EN

Field

Medicine (Health Sciences)