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Biocompatibility studies on biodegradable polyester-based composites of human osteoblasts: A preliminary screening by L. Calandrelli; B. Immirzi; M. Malinconico; G. Orsello; M. G. Volpe; F. Della Ragione; V. Zappia; A. Oliva is a Medicine article available to read on EtoBox.
What is Biocompatibility studies on biodegradable polyester-based composites of human osteoblasts: A preliminary screening about?
## Abstract A series of biodegradable composites with natural hydroxyapatite, designed for possible use in orthopedics applications, were preliminarily screened for biocompatibility by employing primary cultures of human osteoblasts in a direct contact method. The cells were seeded at low density onto the materials under investigation and allowed to grow for 2 weeks. They then were analyzed for morphology, proliferation, viability, alkaline phosphatase activity (AP), osteocalcin (OC) production, and extracellular matrix mineralization. The results showed that all materials have good biocompatibility. Cell viability tests demonstrated that in all cases the values were comparable to the control, and the addition of hydroxyapatite always resulted in an enhancement of performance with respect to the plain polymer. AP and OC analysis confirmed that all composites allowed the expression of phenotypic markers. Scanning electron microscopy provided direct evidence of intense cell adhesion and proliferation on the tested materials. © 2001 Wiley Periodicals, Inc. J Biomed Mater Res 59: 611–617, 2002
Who reads Biocompatibility studies on biodegradable polyester-based composites of human osteoblasts: A preliminary screening?
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- Author
- L. Calandrelli; B. Immirzi; M. Malinconico; G. Orsello; M. G. Volpe; F. Della Ragione; V. Zappia; A. Oliva
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)