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Can I read Impact of Metformin Treatment During Pregnancy on Maternal Outcomes: a Systematic Review/meta-analysis on EtoBox?
Impact of Metformin Treatment During Pregnancy on Maternal Outcomes: a Systematic Review/meta-analysis by Tarry-Adkins, Jane L. (author);Ozanne, Susan E. (author);Aiken, Catherine E. (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Impact of Metformin Treatment During Pregnancy on Maternal Outcomes: a Systematic Review/meta-analysis about?
We systematically assessed the impact of metformin treatment on maternal pregnancy outcomes. PubMed, Ovid Embase, Medline, Web of Science, ClinicalTrials.gov and Cochrane databases were systematically searched (inception-1st February 2021). Randomised controlled trials reporting pregnancy outcomes in women randomised to metformin versus any other treatment for any indication were included. Outcomes included gestational weight gain (GWG), pre-eclampsia, gestational hypertension, preterm birth, gestational age at delivery, caesarean section, gestational diabetes, glycaemic control, and gastrointestinal side-effects. Two independent reviewers conducted screening, with a third available to evaluate disagreements. Risk-of-bias and GRADE assessments were conducted using Cochrane Risk-of-Bias and GRADE-pro software. Thirty-five studies (n = 8033 pregnancies) met eligibility criteria. GWG was lower in pregnancies randomised to metformin versus other treatments (1.57 kg ± 0.60 kg; I~2~ = 86%, __p__ < 0.0001), as was likelihood of pre-eclampsia (OR 0.69, 95% CI 0.50–0.95; I~2~ = 55%, __p__ = 0.02). The risk of gastrointestinal side-effects was greater in metformin-exposed versus other treatm
Who reads Impact of Metformin Treatment During Pregnancy on Maternal Outcomes: a Systematic Review/meta-analysis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Tarry-Adkins, Jane L. (author);Ozanne, Susan E. (author);Aiken, Catherine E. (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)