Can I read Betapapillomavirus Infection Profiles in Tissue Sets from Cutaneous Squamous Cell-carcinoma Patients on EtoBox?

Betapapillomavirus Infection Profiles in Tissue Sets from Cutaneous Squamous Cell-carcinoma Patients by Elsemieke I. Plasmeijer; Rachel E. Neale; Petra G. Buettner; Maurits N.C. de Koning; Jan ter Schegget; Wim G.V. Quint; Adele C. Green; Mariet C.W. Feltkamp is a Medicine article available to read on EtoBox.

What is Betapapillomavirus Infection Profiles in Tissue Sets from Cutaneous Squamous Cell-carcinoma Patients about?

## Abstract Human papillomaviruses from the genus beta (betaPV) are a possible cause of cutaneous squamous cell carcinoma (SCC). We compared the betaPV infections in SCC and in sets of cutaneous tissues collected from a series of individual SCC patients to determine concordance and to assess the adequacy of eyebrow hairs as noninvasive markers of betaPV infection. Biopsies of SCC tumors, perilesional tissue, normal skin from the mirror image of nonfacial SCC and plucked eyebrow hairs were collected from 21 patients with incident SCC living in Queensland, Australia. These were tested for the presence of DNA from 25 different betaPV types. Overall prevalence of betaPV was high in every sample type, ranging from 81% to 95%. The median number of types was significantly higher in the SCC tumour (6), perilesional skin (5) and eyebrow hairs (5) than in normal skin (2). Comparing SCC tissue with other sample types within patients showed 63 overlapping infections with eyebrow hairs (71%; 95% CI: 60–80); 56 with perilesional skin samples (63%; 95% CI: 52–73) and 23 with normal skin samples (26%; 95% CI: 17–36). The sensitivity of eyebrow hair testing for detection of betaPV in the tumor was

Who reads Betapapillomavirus Infection Profiles in Tissue Sets from Cutaneous Squamous Cell-carcinoma Patients?

Author

Elsemieke I. Plasmeijer; Rachel E. Neale; Petra G. Buettner; Maurits N.C. de Koning; Jan ter Schegget; Wim G.V. Quint; Adele C. Green; Mariet C.W. Feltkamp

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2010

Language

EN

Field

Medicine (Health Sciences)