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Epithelial to Mesenchymal Transition During Mammalian Neural Crest Cell Delamination by Ruonan Zhao; Paul A. Trainor is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Epithelial to Mesenchymal Transition During Mammalian Neural Crest Cell Delamination about?

Epithelial to mesenchymal transition (EMT) is a well-defined cellular process that was discovered in chicken embryos and described as "epithelial to mesenchymal transformation" [1]. During EMT, epithelial cells lose their epithelial features and acquire mesenchymal character with migratory potential. EMT has subsequently been shown to be essential for both developmental and pathological processes including embryo morphogenesis, wound healing, tissue fibrosis and cancer [2]. During the past 5 years, interest and study of EMT especially in cancer biology have increased exponentially due to the implied role of EMT in multiple aspects of malignancy such as cell invasion, survival, stemness, metastasis, therapeutic resistance and tumor heterogeneity [3]. Since the process of EMT in embryogenesis and cancer progression shares similar phenotypic changes, core transcription factors and molecular mechanisms, it has been proposed that the initiation and development of carcinoma could be attributed to abnormal activation of EMT factors usually required for normal embryo development. Therefore, developmental EMT mechanisms, whose timing, location, and tissue origin are strictly regulated, coul

Who reads Epithelial to Mesenchymal Transition During Mammalian Neural Crest Cell Delamination?

Author

Ruonan Zhao; Paul A. Trainor

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)