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Fully Automated Closed-loop Insulin Delivery in Adults with Type 2 Diabetes: an Open-label, Single-center, Randomized Crossover Trial by Aideen B. Daly; Charlotte K. Boughton; Munachiso Nwokolo; Sara Hartnell; Malgorzata E. Wilinska; Alina Cezar; Mark L. Evans; Roman Hovorka is a Medicine article available to read on EtoBox.

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## Abstract In adults with type 2 diabetes, the benefits of fully closed-loop insulin delivery, which does not require meal bolusing, are unclear. In an open-label, single-center, randomized crossover study, 26 adults with type 2 diabetes (7 women and 19 men; (mean ± s.d.) age, 59 ± 11 years; baseline glycated hemoglobin (HbA1c), 75 ± 15 mmol mol^−1^ (9.0% ± 1.4%)) underwent two 8-week periods to compare the CamAPS HX fully closed-loop app with standard insulin therapy and a masked glucose sensor (control) in random order, with a 2-week to 4-week washout between periods. The primary endpoint was proportion of time in target glucose range (3.9–10.0 mmol l^−1^). Analysis was by intention to treat. Thirty participants were recruited between 16 December 2020 and 24 November 2021, of whom 28 were randomized to two groups (14 to closed-loop therapy first and 14 to control therapy first). Proportion of time in target glucose range (mean ± s.d.) was 66.3% ± 14.9% with closed-loop therapy versus 32.3% ± 24.7% with control therapy (mean difference, 35.3 percentage points; 95% confidence interval (CI), 28.0–42.6 percentage points; __P__ 10.0 mmol l^−1^ was 33.2% ± 14.8% with closed-loop the

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Author

Aideen B. Daly; Charlotte K. Boughton; Munachiso Nwokolo; Sara Hartnell; Malgorzata E. Wilinska; Alina Cezar; Mark L. Evans; Roman Hovorka

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)