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Permanent Rescue of Lesioned Neonatal Motoneurons and Enhanced Axonal Regeneration by Adenovirus-mediated Expression of Glial Cell-line-derived Neurotrophic Factor by Brian J. Baumgartner; H. D. Shine is a Neuroscience article available to read on EtoBox.

What is Permanent Rescue of Lesioned Neonatal Motoneurons and Enhanced Axonal Regeneration by Adenovirus-mediated Expression of Glial Cell-line-derived Neurotrophic Factor about?

Axotomy of peripheral nerves in neonatal rats induces motoneuron death that can be delayed but not arrested by the application of several neurotrophic factors (NFs) or adenoviral vectors carrying genes for NFs. We tested whether an adenoviral vector carrying the gene for glial cell-line-derived neurotrophic factor (Adv.RSV-GDNF) would prevent neonatal motoneuron death after facial nerve transection or crush. Nerve transection eliminates the pathway for axonal regeneration, while nerve crush preserves the pathway necessary for target reinnervation that may be required for the permanent rescue of motoneurons. Both types of injury cause substantial motoneuron death in neonatal animals. Adv.RSV-GDNF or a control vector carrying the ␤-galactosidase gene (Adv.RSV-␤gal) was injected into facial muscles 2 days before the nerve was transected, or Adv.RSV-GDNF, Adv.RSV-␤gal, Adv.dl312 (a vector lacking a transgene), or vehicle was injected into facial muscles immediately after nerve crush. Four weeks after nerve transection, few motoneurons survived after Adv.RSV-GDNF and Adv.RSV-␤gal treatment (6.1% and 2.4%, respectively). Four weeks after nerve crush, 40% of the motoneurons survived after

Who reads Permanent Rescue of Lesioned Neonatal Motoneurons and Enhanced Axonal Regeneration by Adenovirus-mediated Expression of Glial Cell-line-derived Neurotrophic Factor?

Author

Brian J. Baumgartner; H. D. Shine

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

1998

Language

EN

Field

Neuroscience (Life Sciences)