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Thioporidiols A and B: Two New Sulfur Compounds Discovered by Molybdenum-Catalyzed Oxidation Screening from Trichoderma polypori FKI-7382 by Matsuo, Hirotaka; Noguchi, Yoshihiko; Miyano, Rei; Higo, Mayuka; Nonaka, Kenichi; Sunazuka, Toshiaki; Takahashi, YÅko; Åmura, Satoshi; Nakashima, Takuji is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Two new sulfur compounds, designated thioporidiol A (**1**) and B (**2**), were discovered by the MoS-screening program from a culture broth of __Trichoderma__ __polypori__ FKI-7382. The structures of **1** and **2** were determined as C13 lipid structures with an __N__-acetylcysteine moiety. The relative configuration at the C-5 and C-6 position of **1** was determined by the derivatives of α-methoxy-α-phenylacetic acid diesters, and the absolute configuration of the __N__-acetylcysteine moiety was determined by advanced Marfey’s analysis. Compounds **1** and **2** were evaluated for anti-microbial, cytotoxic and anti-malarial activities. Compound **2** exhibited anti-microbial activity against __Candida albicans__ ATCC 64548.

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Author

Matsuo, Hirotaka; Noguchi, Yoshihiko; Miyano, Rei; Higo, Mayuka; Nonaka, Kenichi; Sunazuka, Toshiaki; Takahashi, YÅko; Åmura, Satoshi; Nakashima, Takuji

Publisher

MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI AG, 2012- (ISSN 2079-6382)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)