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Association of the Interleukin‐1 Gene Cluster on Chromosome 2Q13 with Knee Osteoarthritis by John Loughlin; Barbara Dowling; Zehra Mustafa; Kay Chapman is a Medicine article available to read on EtoBox.

What is Association of the Interleukin‐1 Gene Cluster on Chromosome 2Q13 with Knee Osteoarthritis about?

## Abstract ## Objective To investigate whether the interleukin‐1 (IL‐1) ligand gene cluster at 2q13 encodes for genetic susceptibility to primary osteoarthritis (OA). ## Methods Seven single‐nucleotide polymorphisms (SNPs) and a variable‐number tandem repeat (VNTR) polymorphism from within the IL‐1 ligand genes __IL1A__, __IL1B__, and __IL1RN__ were genotyped in a cohort of 557 OA cases and 557 age‐matched controls. ## Results None of the variants demonstrated association in the unstratified data set. However, when cases were stratified according to sex and site of disease (hip or knee), 4 SNPs showed marginal evidence for association (__P__ < 0.1) in knee cases (n = 136) and male knee cases (n = 58). For 2 of these SNPs, evidence for association was enhanced when probands from 60 knee‐only affected sibling pair families were genotyped and combined with the original knee cases (__P__ ≤ 0.05). Further analysis revealed that the associated alleles at 2 of these SNPs were markers for the same haplotype, the frequency of which was significantly elevated when knee cases and knee probands were combined (__P__ = 0.01, odds ratio [OR] 1.4) and when male knee cases and male knee probands w

Who reads Association of the Interleukin‐1 Gene Cluster on Chromosome 2Q13 with Knee Osteoarthritis?

Author

John Loughlin; Barbara Dowling; Zehra Mustafa; Kay Chapman

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)

Published

2002

Language

EN

Field

Medicine (Health Sciences)