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This study establishes physiologically based pharmacokinetic (PBPK) models for the anti-cancer drug famitinib in rats and monkeys to predict its pharmacokinetics and tissue distribution in humans. The models were optimized using GastroPlus and showed good correlation with observed data, indicating their reliability for predicting human pharmacokinetics. The findings suggest that the PBPK model can be useful for future studies on drug-drug interactions involving famitinib.

Author

wyiru054

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EN