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Stereodivergent Photobiocatalytic Radical Cyclization Through The Repurposing and Directed Evolution of Fatty Acid Photodecarboxylases by Koko Kgk is a document available to read on EtoBox.
What is Stereodivergent Photobiocatalytic Radical Cyclization Through The Repurposing and Directed Evolution of Fatty Acid Photodecarboxylases about?
This article discusses the engineering of fatty acid photodecarboxylases to create stereodivergent radical photocyclases for unnatural C–C bond formation. Through genome mining, directed evolution, and high-throughput experimentation, the authors developed enzymes that achieve excellent chemo-, enantio-, and diastereoselectivities in radical cyclization reactions. The findings highlight the potential of repurposing natural photoenzymes for new synthetic applications in asymmetric radical biocatalysis.
- Author
- Koko Kgk
- Language
- EN