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Determination of aflatoxin M1 and deoxynivalenol biomarkers in infants and children urines from Bangladesh by Nurshad Ali; M. Manirujjaman; Sohel Rana; Gisela H. Degen is a Environmental Science article available to read on EtoBox.

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## Abstract The mycotoxins aflatoxin B~1~ (AFB~1~) and deoxynivalenol (DON) are found worldwide in crops and dietary staples. The prevalence and levels of these contaminants can vary greatly, and data in Bangladeshi food commodities are scarce. To characterize human exposure, we have conducted biomonitoring, analyzing AFM~1~ (a metabolite of AFB~1~) and DON levels in urines of adult cohorts in Bangladesh. Yet, AFM~1~ and DON occurrence has not been studied in the very young population of this country. Thus, the same methods, HPLC-FD for AFM~1~ and LC–MS/MS for DON analysis, were now applied to determine these biomarkers in urines of infants (n = 49) and young children (n = 105) in Rajshahi and Dhaka district. Overall, AFM~1~ and DON detection frequency was 43.5% and 33.4%, with 34.7% and 11.5% in infant and 47.6% and 39.4% in children urines, respectively. The mean AFM~1~ levels in all infants (9.1 ± 14.3, max 55.6 pg/mL) and children (8.8 ± 12.9, max 75.3 pg/mL) were not significantly different. The AFM~1~ mean level was slightly higher in Dhaka (9.4 ± 12.4) compared to Rajshahi (8.5 ± 13.9 pg/mL) district. The average DON level was about 2-fold higher in infant (3.8 ± 2.9, max 6.

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Author

Nurshad Ali; M. Manirujjaman; Sohel Rana; Gisela H. Degen

Publisher

Springer Science and Business Media LLC

Published

2020

Language

EN

Field

Environmental Science (Life Sciences)