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Direction of neutrophil movements by Campylobacter-infected intestinal epithelium by Helen Murphy; Tristan Cogan; Tom Humphrey is a Medicine article available to read on EtoBox.

What is Direction of neutrophil movements by Campylobacter-infected intestinal epithelium about?

Campylobacter jejuni and Campylobacter coli together represent the leading bacterial cause of human enteritis. However, the pathogenesis of this disease is poorly understood. Infection results in the formation of crypt abscesses resulting from the migration of neutrophils across the intestinal epithelium and into the intestinal crypts. In this study, we model this process in vitro and show that Campylobacter infection of epithelium results in a quantifiable increase in the directed movement of neutrophils from the basolateral to apical surface of the epithelium. This process is dependent on both bacterially derived n-formyl peptides and on the host cell enzyme 12-lipoxygenase (12-LOX).

Who reads Direction of neutrophil movements by Campylobacter-infected intestinal epithelium?

Author

Helen Murphy; Tristan Cogan; Tom Humphrey

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1286-4579)

Published

2011

Language

EN

Field

Medicine (Life Sciences)