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Myocardial perfusion in excessively trabeculated hearts: Insights from imaging and histological studies by Bjarke Jensen; Steffen E. Petersen; Bram F. Coolen is a Medicine article available to read on EtoBox.

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In gestation, the coronary circulation develops initially in the compact layer and it expands only in fetal development to the trabeculations. Conflicting data have been published as to whether the trabecular layer is hypoperfused relative to the compact wall after birth. If so, this could explain the poor pump function in patients with left ventricular excessive trabeculation, or so-called noncompaction. Here, we review direct and indirect assessments of myocardial perfusion in normal and excessively trabeculated hearts by in vivo imaging by magnetic resonance imaging (MRI), positron emission tomography (PET)/single photon emission computed tomography (SPECT), and echocardiography in addition to histology, injections of labelled microspheres in animals, and electrocardiography. In MRI, PET/SPECT, and echocardiography, flow of blood or myocardial uptake of blood-borne tracer molecules are measured. The imaged trabecular layer comprises trabeculations and blood-filled intertrabecular spaces whereas the compact layer comprises tissue only, and spatio-temporal resolution likely affects measurements of myocardial perfusion differently in the two layers. Overall, studies measuring myoca

Who reads Myocardial perfusion in excessively trabeculated hearts: Insights from imaging and histological studies?

Author

Bjarke Jensen; Steffen E. Petersen; Bram F. Coolen

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)