Can I read Anticomplement activity of polyacetylenes from leaves of Dendropanax morbifera Leveille on EtoBox?

Anticomplement activity of polyacetylenes from leaves of Dendropanax morbifera Leveille by Ill‐Min Chung; Hong‐Keun Song; Sun‐Jin Kim; Hyung‐In Moon is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Anticomplement activity of polyacetylenes from leaves of Dendropanax morbifera Leveille about?

## Abstract The present study evaluated the anticomplement effect of polyacetylenes from __Dendropanax morbifera__ (Araliaceae) in the classical pathway complement system. The leaves of __D. morbifera__ were evaluated with regard to its anticomplement activity, and its active principles identified following activity‐guided isolation. An aqueous CCl~4~ fraction of the leaves of __D. morbifera__ exhibited significant anticomplement activity on the classical pathway complement system, which was expressed as total hemolytic activity. Three polyacetylenes isolated from the leaves of __D. morbifera__, namely (3__S__)‐falcarinol (1), (3__S__,8__S__)‐falcarindiol (2) and (3__S__)‐diynene (3). Compounds 1, 2 and 3 showed inhibitory activity against complement system with 50% inhibitory concentrations (IC~50~) values of 87.3 μm, 15.2 μm and 39.8 μm. Among the compounds tested, 2 showed the most potent anticomplement activity (IC~50~, 15.2 μm). Copyright © 2010 John Wiley & Sons, Ltd.

Who reads Anticomplement activity of polyacetylenes from leaves of Dendropanax morbifera Leveille?

Author

Ill‐Min Chung; Hong‐Keun Song; Sun‐Jin Kim; Hyung‐In Moon

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)