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ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA by Hiroshi Ishiguchi; Hiroto Izumi; Takayuki Torigoe; Yoichiro Yoshida; Hiroshi Kubota; Sadatoshi Tsuji; Kimitoshi Kohno is a Medicine article available to read on EtoBox.

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## Abstract We have identified a cisplatin‐inducible gene, the __mitochondrial ribosomal protein S11__ (__MRP S11__) gene, by means of mRNA differential display. Functional analysis of the __MRP__ S11 promoter showed that a Staf binding site in the promoter is required for both basal promoter activity and cisplatin‐inducible activity. We also found that Staf binding activity is significantly increased in nuclear extracts from cells treated with cisplatin. ZNF 143 and ZNF 76 are human homologues of the Xenopus transcriptional activator, Staf. __ZNF 143__ expression is induced by cisplatin but __ZNF 76__ expression is not. However, __ZNF 143__ expression is not induced by transplatin, which is clinically ineffective. __ZNF143__ is an inducible gene by other DNA damaging agents such as γ‐irradiation, etoposide and adriamycin. ZNF 143 also binds preferentially to cisplatin‐modified DNA. These results suggest that ZNF 143 participates in cellular responses to DNA damage. © 2004 Wiley‐Liss, Inc.

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Author

Hiroshi Ishiguchi; Hiroto Izumi; Takayuki Torigoe; Yoichiro Yoshida; Hiroshi Kubota; Sadatoshi Tsuji; Kimitoshi Kohno

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2004

Language

EN

Field

Medicine (Health Sciences)