Can I read Hepatocyte growth factor (HGF) produced by peritoneal fibroblasts may affect mesothelial cell morphology and promote peritoneal dissemination on EtoBox?
Hepatocyte growth factor (HGF) produced by peritoneal fibroblasts may affect mesothelial cell morphology and promote peritoneal dissemination by Masakazu Yashiro; Yong-Suk Chung; Tohru Inoue; Shigehiko Nishimura; Tasuku Matsuoka; Tomofumi Fujihara; Michio Sowa is a Medicine article available to read on EtoBox.
What is Hepatocyte growth factor (HGF) produced by peritoneal fibroblasts may affect mesothelial cell morphology and promote peritoneal dissemination about?
Mesothelial cell monolayers have been reported to infiltration of cancer cells into the peritmum. Gt previously reported that peritoneal fibrosis induced by gastric cancer cells prior to metastatization may provide a congenial environment for peritoneal mtastases. In this study, we investigatedtheeffectsofperitonealfibroblastsonperitoncalmesotheliil cell morphology. Human gastric cancer (OCUM-ZMD3). peritoneal fibroblast (NF-ZP) and mesothelial (MS-I) cell lines ware established in our laboratory. Histology of the peritoneum was investigated following intrap\*itoncal inoculation of serumfree conditioned media (SF-CM) from OCUM-ZMD3 celk into nude mice. SF-CM horn peritoneal fibroblasts was added to mondayer-cultured merothelial celk, and their morphology was examined by phase-contrast microscopy. This experiment was conducted in the presence and absemce of neutralizing antibodies against various factors. Mesothelial celk exposed to fibroblasts proliferation became hemispherical and separated from each other, while unexpOScd mesothelium mmained as a flat monolayer. Cultured-memthelial cells rounded up or urhibited a fibroblast-like shape following the addition of fibroblast SF-CM. A
Who reads Hepatocyte growth factor (HGF) produced by peritoneal fibroblasts may affect mesothelial cell morphology and promote peritoneal dissemination?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Masakazu Yashiro; Yong-Suk Chung; Tohru Inoue; Shigehiko Nishimura; Tasuku Matsuoka; Tomofumi Fujihara; Michio Sowa
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)