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Can I read Body mass index and risk of infections: a Mendelian randomization study of 101,447 individuals on EtoBox?
Body mass index and risk of infections: a Mendelian randomization study of 101,447 individuals by Winter-Jensen, Matilde; Afzal, Shoaib; Jess, Tine; Nordestgaard, BÃ ̧rge G.; Allin, Kristine H. is a Medicine article available to read on EtoBox.
What is Body mass index and risk of infections: a Mendelian randomization study of 101,447 individuals about?
Body mass index (BMI) has been related to risk of infections. The aim of this study was to assess the shape of the association between BMI and risk of infections and to evaluate whether such associations represent causality. We included 101,447 individuals from The Copenhagen General Population Study who had BMI measured. Outcome was hospital contacts related to infections. The shape of the association between BMI and risk of infections was examined using restricted cubic spline Cox regression. To evaluate causality, we used Mendelian randomization, an epidemiological method that counteracts confounding and reverse causality by using genetic variation as instrumental variables. We created a genetic risk score based on five genetic variants causing lifelong higher BMI and used this score in instrumental variable analysis. During median follow-up of 8.8 years, 10,263 hospital contacts related to infections were recorded. We found a U-shaped association between BMI and risk of any infection and pneumonia, and a linear association between BMI and risk of skin infection, urinary tract infection, and sepsis. In instrumental variable analyses, higher BMI was associated with increased risk
Who reads Body mass index and risk of infections: a Mendelian randomization study of 101,447 individuals?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Winter-Jensen, Matilde; Afzal, Shoaib; Jess, Tine; Nordestgaard, BÃ ̧rge G.; Allin, Kristine H.
- Publisher
- Springer; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0393-2990)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)