Can I read Traumatic Brain Injury Results in Disparate Regions of Chondroitin Sulfate Proteoglycan Expression That Are Temporally Limited on EtoBox?

Traumatic Brain Injury Results in Disparate Regions of Chondroitin Sulfate Proteoglycan Expression That Are Temporally Limited by N.G. Harris; S.T. Carmichael; D.A. Hovda; R.L. Sutton is a Neuroscience article available to read on EtoBox.

What is Traumatic Brain Injury Results in Disparate Regions of Chondroitin Sulfate Proteoglycan Expression That Are Temporally Limited about?

## Abstract Axonal injury is a major hallmark of traumatic brain injury (TBI), and it seems likely that therapies directed toward enhancing axon repair could potentially improve functional outcomes. One potential target is chondroitin sulfate proteoglycans (CSPGs), which are major axon growth inhibitory molecules that are generally, but not always, up‐regulated after central nervous system injury. The current study was designed to determine temporal changes in cerebral cortical mRNA or protein expression levels of CSPGs and to determine their regional localization and cellular association by using immunohistochemistry in a controlled cortical impact model of TBI. The results showed significant increases in versican mRNA at 4 and 14 days after TBI but no change in neurocan, aggrecan, or phosphacan. Semiquantitative Western blot (WB) analysis of cortical CSPG protein expression revealed a significant ipsilateral decrease of all CSPGs at 1 day after TBI. Lower CSPG protein levels were sustained until at least 14 days, after which the levels began to normalize. Immunohistochemistry data confirm previous reports of regional __increases__ in CSPG proteins after CNS injury, seen primarily

Who reads Traumatic Brain Injury Results in Disparate Regions of Chondroitin Sulfate Proteoglycan Expression That Are Temporally Limited?

Author

N.G. Harris; S.T. Carmichael; D.A. Hovda; R.L. Sutton

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

2009

Language

EN

Field

Neuroscience (Life Sciences)