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Multipoint Methylation Analysis Indicates a Distinctive Epigenetic Phenotype Among Testicular Germ Cell Tumors and Testicular Malignant Lymphomas by Takahiro Kawakami; Keisei Okamoto; Akira Kataoka; Shuichi Koizumi; Hideaki Iwaki; Hiroyuki Sugihara; Anthony E. Reeve; Osamu Ogawa; Yusaku Okada is a Medicine article available to read on EtoBox.
What is Multipoint Methylation Analysis Indicates a Distinctive Epigenetic Phenotype Among Testicular Germ Cell Tumors and Testicular Malignant Lymphomas about?
## Abstract Hypermethylation of tumor‐suppressor genes has been implicated in the pathogenesis of human cancers. Although a growing number of genes showing hypermethylation is being reported in human cancer, methylation profiles of tumor‐related genes in testicular neoplasms have not been well elucidated. This study was designed to show the methylation profiles of multiple CpG islands in testicular germ cell tumors (TGCTs) in comparison with those in testicular malignant lymphomas. We studied the methylation status of E‐cadherin, __CDKN2B__, __CDKN2A__, __BRCA1__, __RB1__, __VHL__, __RASSF1A__, __RARB__, and __GSTP1__ by use of TGCT tissues and testicular malignant lymphoma tissues (25 primary TGCT tissues and three primary testicular lymphoma tissues). Methylation was not observed in E‐cadherin, __CDKN2B__, __CDKN2A__, __BRCA1__, __RB1__, __VHL__, __RASSF1A__, __RARB__, and __GSTP1__ in any of the TGCT tissues. In contrast, all three (100%) of the testicular lymphoma tissues demonstrated hypermethylation of E‐cadherin, __RASSF1A__, and __RARB__, but not __CDKN2B__, __CDKN2A__, __BRCA1__, __RB1__, __VHL__, and __GSTP1__. These data demonstrate that a distinctive epigenetic phenotyp
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- Author
- Takahiro Kawakami; Keisei Okamoto; Akira Kataoka; Shuichi Koizumi; Hideaki Iwaki; Hiroyuki Sugihara; Anthony E. Reeve; Osamu Ogawa; Yusaku Okada
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Life Sciences)