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Normal and clonal B lineage cells can be distinguished by their differential expression of B cell antigens and adhesion molecules in peripheral blood from multiple myeloma (MM) patients—diagnostic and clinical implications by R Luque; J A Brieva; A Moreno; A Manzanal; L Escribano; J Villarrubia; J L Velasco; J López-Jiménez; C Cerveró; M J Otero; J Martínez; C Bellas; E Roldán is a Immunology and Microbiology article available to read on EtoBox.

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## SUMMARY Human MM is a haematologic disorder characterized by the accumulation of malignant plasma cells (PC), primarily in the bone marrow (BM). Although these cells characteristically home to the BM, in recent years several groups have detected the presence of related malignant B cells in the peripheral blood (PB) which could be implicated in the progression and spread of the disease. However, the proportion and origin of these clonotypic circulating B cells is still controversial. In this study, using a triple-staining flow cytometric procedure and a whole blood lysis method, PB B lineage cells could be divided into two populations according to their distinct repertoires of cell adhesion molecules and B cell antigens in untreated MM patients. The results show that: (i) the percentage and the absolute number of PB CD19+ B cells were decreased in MM patients compared with controls; (ii) the quantity and percentage of B cell antigens (CD20, CD22, CD24, DR, CD138) and adhesion molecules (β1- and β2-integrins, CD44, CD54, CD56, CD61 and CD62L) expressed by these PB CD19+ cells of MM patients and healthy subjects were similar and all of them were virtually polyclonal cells; (iii) a

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Author

R Luque; J A Brieva; A Moreno; A Manzanal; L Escribano; J Villarrubia; J L Velasco; J López-Jiménez; C Cerveró; M J Otero; J Martínez; C Bellas; E Roldán

Publisher

Oxford University Press (OUP)

Published

1998

Language

EN

Field

Immunology and Microbiology (Life Sciences)