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Can I read Synovial Extracellular Vesicles: Structure and Role in Synovial Fluid Tribological Performances on EtoBox?
Synovial Extracellular Vesicles: Structure and Role in Synovial Fluid Tribological Performances by Layth Ben-Trad; Constantin Ionut Matei; Mirela Maria Sava; Samira Filali; Marie-Eve Duclos; Yves Berthier; Michel Guichardant; Nathalie Bernoud-Hubac; Ofelia Maniti; Ahmed Landoulsi; Marie-Genevieve Blanchin; Pierre Miossec; Thierry Granjon; Ana-Maria Trunfio-Sfarghiu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synovial Extracellular Vesicles: Structure and Role in Synovial Fluid Tribological Performances about?
The quality of the lubricant between cartilaginous joint surfaces impacts the joint's mechanistic properties. In this study, we define the biochemical, ultrastructural, and tribological signatures of synovial fluids (SF) from patients with degenerative (osteoarthritis-OA) or inflammatory (rheumatoid arthritis-RA) joint pathologies in comparison with SF from healthy subjects. Phospholipid (PL) concentration in SF increased in pathological contexts, but the proportion PL relative to the overall lipids decreased. Subtle changes in PL chain composition were attributed to the inflammatory state. Transmission electron microscopy showed the occurrence of large multilamellar synovial extracellular vesicles (EV) filled with glycoprotein gel in healthy subjects. Synovial extracellular vesicle structure was altered in SF from OA and RA patients. RA samples systematically showed lower viscosity than healthy samples under a hydrodynamic lubricating regimen whereas OA samples showed higher viscosity. In turn, under a boundary regimen, cartilage surfaces in both pathological situations showed high wear and friction coefficients. Thus, we found a difference in the biochemical, tribological, and ul
Who reads Synovial Extracellular Vesicles: Structure and Role in Synovial Fluid Tribological Performances?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Layth Ben-Trad; Constantin Ionut Matei; Mirela Maria Sava; Samira Filali; Marie-Eve Duclos; Yves Berthier; Michel Guichardant; Nathalie Bernoud-Hubac; Ofelia Maniti; Ahmed Landoulsi; Marie-Genevieve Blanchin; Pierre Miossec; Thierry Granjon; Ana-Maria Trunfio-Sfarghiu
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)