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Can I read 163. Longitudinal Associations Between Ventral Striatum Activity and Depression and Anhedonia Symptoms in a Brazilian Cohort of Adolescents on EtoBox?
163. Longitudinal Associations Between Ventral Striatum Activity and Depression and Anhedonia Symptoms in a Brazilian Cohort of Adolescents by Madeleine Frazier; Leehyun Yoon; Fernanda Rohrsetzer; Laila Souza; Jader Piccin; Helen L. Fisher; Brandon A. Kohrt; Valeria Mondelli; Christian Kieling; Johnna R. Swartz is a Neuroscience article available to read on EtoBox.
What is 163. Longitudinal Associations Between Ventral Striatum Activity and Depression and Anhedonia Symptoms in a Brazilian Cohort of Adolescents about?
Results: Crh+ CeA cells were classified into ensembles during low-threat offensive aggression testse 41% were active before attack initiation, 32% were active during attacks, and 27% were inactive during aggression. Chemogenetic inhibition of Crh+ amygdala cells selectively prevented offensive attacks without affecting social approach, contact, or adaptive selfdefensive bites toward an attacking intruder.Conclusions: Crh+ amygdala cell activity is necessary for the initiation of offensive attacks toward a low-threat intruder, but not for self-defensive bites, suggesting distinct neural circuitry underlying offensive vs. self-defensive aggression. All-optical closed-loop approaches are being used to block attack initiation using Crh+ CeA cell activity to trigger real-time inhibitory optogenetics.
Who reads 163. Longitudinal Associations Between Ventral Striatum Activity and Depression and Anhedonia Symptoms in a Brazilian Cohort of Adolescents?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Madeleine Frazier; Leehyun Yoon; Fernanda Rohrsetzer; Laila Souza; Jader Piccin; Helen L. Fisher; Brandon A. Kohrt; Valeria Mondelli; Christian Kieling; Johnna R. Swartz
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)