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Prevalence and antimicrobial resistance patterns of bacteria isolated from cerebrospinal fluid among children with bacterial meningitis in China from 2016 to 2018: a multicenter retrospective study by the Collaborative Working Group of the Pediatric Subgroup of the China Society of Infectious Diseases (author);Peng, Xiaoshan (author);Zhu, Qingxiong (author);Liu, Jing (author);Zeng, Mei (author);Qiu, Yue (author);Zhu, Chunhui (author);Cheng, Yibing (author);Zhou, Yibo (author);Xu, Yi (author);Chen, Minxia (author);Wen, Zhengwang (author);Chen, Yiping (author);Li, Rui (author);Tong, Jianning (author);Shan, Qingwen (author);Lin, Daojiong (author);Wu, Shouye (author);Zhuo, Zhiqiang (author);Wang, Caihong (author);Zhao, Shiyong (author);Qi, Zhenghong (author);Sun, Xiaofeng (author);Maihebuba, Bieerding (author);Jia, Chunmei (author);Gao, Huiling (author);Li, Shuangjie (author);Zhu, Yu (author);Wan, Chaomin (author) is a Medicine article available to read on EtoBox.

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## Abstract ## Background Pediatric bacterial meningitis (PBM) remains a devastating disease that causes substantial neurological morbidity and mortality worldwide. However, there are few large-scale studies on the pathogens causing PBM and their antimicrobial resistance (AMR) patterns in China. The present multicenter survey summarized the features of the etiological agents of PBM and characterized their AMR patterns. ## Methods Patients diagnosed with PBM were enrolled retrospectively at 13 children’s hospitals in China from 2016 to 2018 and were screened based on a review of cerebrospinal fluid (CSF) microbiology results. Demographic characteristics, the causative organisms and their AMR patterns were systematically analyzed. ## Results Overall, 1193 CSF bacterial isolates from 1142 patients with PBM were obtained. The three leading pathogens causing PBM were Staphylococcus epidermidis (16.5%), Escherichia coli (12.4%) and Streptococcus pneumoniae (10.6%). In infants under 3 months of age, the top 3 pathogens were E. coli (116/523; 22.2%), Enterococcus faecium (75/523; 14.3%), and S. epidermidis (57/523; 10.9%). However, in children more than 3 months of age, the top 3 pathogens

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Author

the Collaborative Working Group of the Pediatric Subgroup of the China Society of Infectious Diseases (author);Peng, Xiaoshan (author);Zhu, Qingxiong (author);Liu, Jing (author);Zeng, Mei (author);Qiu, Yue (author);Zhu, Chunhui (author);Cheng, Yibing (author);Zhou, Yibo (author);Xu, Yi (author);Chen, Minxia (author);Wen, Zhengwang (author);Chen, Yiping (author);Li, Rui (author);Tong, Jianning (author);Shan, Qingwen (author);Lin, Daojiong (author);Wu, Shouye (author);Zhuo, Zhiqiang (author);Wang, Caihong (author);Zhao, Shiyong (author);Qi, Zhenghong (author);Sun, Xiaofeng (author);Maihebuba, Bieerding (author);Jia, Chunmei (author);Gao, Huiling (author);Li, Shuangjie (author);Zhu, Yu (author);Wan, Chaomin (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)