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Significant Adverse Reactions to Long-acting Gonadotropin-releasing Hormone Agonists for the Treatment of Central Precocious Puberty and Early Onset Puberty by Ji Woo Lee; Hyung Jin Kim; Yun Mee Choe; Hee Suk Kang; Soon Ki Kim; Yong Hoon Jun; Ji Eun Lee is a Medicine article available to read on EtoBox.
What is Significant Adverse Reactions to Long-acting Gonadotropin-releasing Hormone Agonists for the Treatment of Central Precocious Puberty and Early Onset Puberty about?
## Purpose Long-acting gonadotropin-releasing hormone agonists (GnRHa) are commonly used to treat central precocious puberty (CPP) in Korea. Although rare, there have been reports on the characteristic of adverse reactions of GnRHa in CPP among the Korean population. This study was intended to report on our clinical experience regarding significant adverse reactions to long-acting GnRHa in CPP and early onset puberty and to evaluate the prevalence rate of serious side effects. ## Methods This retrospective study included children with CPP and early onset puberty, who were administered monthly with long-acting GnRHa (leuprolide acetate, triptorelin acetate) at the outpatient clinic of Department of Pediatrics, at Inha University Hospital, between January 2011 and December 2013. We analyzed the clinical characteristics of patients who experienced significant adverse reactions and evaluated the prevalence rate. ## Results Six serious side effects (0.9%) were observed among total of 621 CPP and early onset puberty children with GnRHa therapy. The number of sterile abscess formation was four in three patients (4 events of 621). Anaphylaxis occurred in only one patient, and unilateral sl
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- Author
- Ji Woo Lee; Hyung Jin Kim; Yun Mee Choe; Hee Suk Kang; Soon Ki Kim; Yong Hoon Jun; Ji Eun Lee
- Publisher
- Korean Society of Pediatric Endocrinology
- Published
- 2014
- Language
- EN
- Field
- Medicine (Health Sciences)