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Natural antioxidant curcumin attenuates NiO nanoparticle-induced cytotoxicity in mouse spermatogonia cells: A mechanistic study by Maqusood Ahamed; Mohd Javed Akhtar; Hisham A. Alhadlaq is a Agricultural and Biological Sciences article available to read on EtoBox.

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Current research focuses on the effects of nanomaterials on the human reproductive system. Nanostructures can cross the epithelial and blood-testicular barriers and pose risks to the reproductive organs. Oxidative stress has been proposed as a possible mechanism of reproductive toxicity caused by nanomaterials. Dietary curcumin could be a therapeutic drug for nanomaterial-induced reproductive toxicity. Studies on effect of commonly used nickel (II) oxide nanoparticle (NiO NPs) on male reproductive organs and their attenuation by natural antioxidant curcumin is scarce. This work intended to study the attenuating potential of curcumin against NiO NPs-induced toxicity in mouse spermatogonia GC-1 spg cells. Plausible mechanisms of alleviating effect curcumin against NiO induced reproductive toxicity was explored through oxidative stress pathway. NiO NPs was synthesized via chemical co-precipitation route and characterized by SEM, TEM, and XRD. NiO NPs was found to induce dose-dependent cytotoxicity in GC-1 spg cells (10–320 μg/ml for 24 h) whereas curcumin did not exert any effect in concentration range of 1–80 μg/ml. Interestingly, cytotoxic response of NiO NPs in GC-1 spg cells was s

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Author

Maqusood Ahamed; Mohd Javed Akhtar; Hisham A. Alhadlaq

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Agricultural and Biological Sciences (Physical Sciences)