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Preparation and Improvement of Release Behavior of Chitosan Microspheres Containing Insulin by Lian-Yan Wang; Yong-Hong Gu; Zhi-Guo Su; Guang-Hui Ma is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Preparation and Improvement of Release Behavior of Chitosan Microspheres Containing Insulin about?

Chitosan microsphere has potential applications in orally and other mucosally administration of protein and peptide drug, because it shows excellent mucoadhesive and permeation enhancing effect across the biological surfaces. The control of the size and size distribution of chitosan microsphere is necessary in order to improve its reproducibility, bioavailability and repeatable release behavior. Furthermore, it is a big challenge how to maintain the chemical stability of protein drug and improve its release behavior in the preparation of chitosan microspheres, because conventional crosslinking method by glutaraldehyde cannot be used in encapsulation of protein drug containing amino group. In this study, we established a method to prepare uniform-sized microsphere, and solve above problems by combining a special membrane emulsification technique and a step-wise crosslinking method. The preparative condition was optimized, and the chemical stability of protein, encapsulation efficiency, and release behavior were compared with conventional preparative method of drug-loaded chitosan microspheres. As a result, fairly uniform chitosan microspheres were obtained with a coefficient of vari

Who reads Preparation and Improvement of Release Behavior of Chitosan Microspheres Containing Insulin?

Author

Lian-Yan Wang; Yong-Hong Gu; Zhi-Guo Su; Guang-Hui Ma

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2006

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)