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This document presents the development of a novel gene-edited rat model of Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL), designated CRHTRA1, which replicates key pathological features of the disease associated with mutations in the HTRA1 gene. The study reports significant cognitive deficits, gait disturbances, and notable cerebral vascular changes in the CRHTRA1 rats, along with alterations in signaling pathways linked to the HTRA1 mutation. This mod

Author

Attahiyyata Yusuf

Language

EN