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Pharmacokinetics and Therapeutic Effects of Oltipraz After Consecutive or Intermittent Oral Administration in Rats with Liver Cirrhosis Induced by Dimethylnitrosamine by Soo K. Bae; Shin J. Lee; Taekrho Kim; Jin W. Kim; Inchul Lee; Sang G. Kim; Myung G. Lee is a Chemistry article available to read on EtoBox.
What is Pharmacokinetics and Therapeutic Effects of Oltipraz After Consecutive or Intermittent Oral Administration in Rats with Liver Cirrhosis Induced by Dimethylnitrosamine about?
Pharmacokinetics and therapeutic effects of oltipraz were evaluated after consecutive (once per day at 30 mg/kg/day for 7 and 14 days) or intermittent (once per week at 100 mg/kg/week for 1-3 weeks) oral administration to rats with liver cirrhosis induced by dimethylnitrosamine. The AUC of oltipraz was significantly greater in cirrhotic rats than controls (890 compared with 270 microg . min/mL) due to impaired liver function in cirrhotic rats. However, the AUC values after consecutive 7 (421 compared with 753 microg . min/mL) and 14 (309 compared with 821 microg . min/mL) days oral administration of oltipraz in cirrhotic rats were significantly smaller than those in respective vehicle-treated cirrhotic rats. Moreover, the AUC values after intermittent 2 and 3 weeks in cirrhotic rats were also significantly smaller than that in 1 week vehicle-treated cirrhotic rats (2370 and 1690 compared with 4760 microg . min/mL). This could be due to induction of CYP isozymes and considerably greater numbers of normal liver cells in cirrhotic rats by oral administration of oltipraz. Improved liver function by oltipraz in cirrhotic rats was proved by liver microscopy; livers are free of significan
Who reads Pharmacokinetics and Therapeutic Effects of Oltipraz After Consecutive or Intermittent Oral Administration in Rats with Liver Cirrhosis Induced by Dimethylnitrosamine?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Soo K. Bae; Shin J. Lee; Taekrho Kim; Jin W. Kim; Inchul Lee; Sang G. Kim; Myung G. Lee
- Publisher
- John Wiley and Sons; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-3549)
- Published
- 2006
- Language
- EN
- Field
- Chemistry (Physical Sciences)