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What is S-Formylglutathione Hydrolase in P. denitrificans about?

The study identifies the fghA gene in Paracoccus denitrificans, which encodes S-formylglutathione hydrolase, showing significant homology to human esterase D. Mutations in fghA lead to a loss of enzyme activity and inability to grow on methylotrophic substrates, indicating its essential role in formaldehyde detoxification. This suggests a universal pathway for formaldehyde detoxification across various organisms.

Author
bfngxgugfgwhosykjm
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