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Electrochemical impedance spectroscopy sensor for ascorbic acid based on copper(I) catalyzed click chemistry by Suyan Qiu; Sen Gao; Qida Liu; Zhenyu Lin; Bin Qiu; Guonan Chen is a Engineering article available to read on EtoBox.

What is Electrochemical impedance spectroscopy sensor for ascorbic acid based on copper(I) catalyzed click chemistry about?

Copper(I) species can be acquired from the reduction of copper(II) by ascorbic acid (AA) in situ, and which in turn quantitative catalyze the azides and alkynes cycloaddition reaction. In this study, propargyl-functionalized ferrocene (propargyl-functionalized Fc) has been modified on the electrode through reacting with azide terminal modified Au electrode via copper(I) catalyzed azides and alkynes cycloaddition (CuAAC) reaction. The electrochemical impedance spectroscopy (EIS) measurement has been applied to test the electron transfer resistance of the Au electrode before and after click reaction. The changes of the fractional surface coverage (θ) with different AA concentrations are characterized. It is found that the θ value has a linear response to the logarithm of AA concentration in the range of 5.0 pmol/L to 1.0 nmol/L with the detection limits of 2.6 pmol/L. The sensor shows a good stability and selectivity. And it has been successfully applied to the AA detection in the real samples (urine) with satisfactory results.

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Author

Suyan Qiu; Sen Gao; Qida Liu; Zhenyu Lin; Bin Qiu; Guonan Chen

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0956-5663)

Published

2011

Language

EN

Field

Engineering (Physical Sciences)